Inter Milan vs Barcelona – UEFA Champions League Semi-final Leg 2 Prediction – May 6, 2025 – San Siro

One of European football’s most iconic venues, San Siro, sets the stage for an electric clash as Inter Milan host Barcelona in the second leg of their UEFA Champions League semi-final on May 6, 2025. With a spot in the final on the line, the tension will be at a boiling point as both giants of the game aim to stamp their ticket to the ultimate showdown.

First Leg Recap: Tightly Contested

The first leg was a tactical masterclass, ending in a narrow 1-0 win for Barcelona at the Camp Nou. Xavi’s side dominated possession, but Inter’s backline, anchored by Alessandro Bastoni, managed to keep the tie within reach. The Blaugrana’s goal came courtesy of Robert Lewandowski, whose clinical finish may prove vital in the aggregate equation.

However, Inter were far from passive. Lautaro Martínez and Nicolò Barella had chances to equalize, and at San Siro—with the Curva Nord in full voice—they’ll be fired up for a comeback.

Tactical Preview: Inter’s Pressure vs Barcelona’s Control

Expect Simone Inzaghi’s Inter to press early and often, using their wingbacks to overload the flanks and create service into the box. Hakan Çalhanoğlu’s set-piece delivery could be a game-changer, especially against Barcelona’s shaky aerial defense.

On the other side, Pedri and Gavi will need to manage the tempo while avoiding midfield turnovers. If Barcelona can survive the opening 20 minutes, they could catch Inter on the break through the pace of Raphinha or João Félix.

Betting Outlook

Barcelona may enter as slight favorites due to the aggregate lead, but betting markets are respecting Inter’s home-field strength. Moneyline odds are nearly even, with the total goals line hovering at 2.5.

Bettors using ev betting models should look closely at Inter to score in both halves—especially with their aggressive start expected. Meanwhile, arbitrage betting fans may find spread value in Barcelona +0.5 across different offshore sportsbook options.

Sharp players on crypto sportsbooks are also getting in early on first goalscorer markets, with Lautaro Martínez and Lewandowski attracting action across bitcoin sportsbook platforms.

Final Prediction

Inter will throw everything at Barcelona, but the Spanish side’s technical poise and counterattack could be the difference. Expect a dramatic night with both teams finding the net—but Barcelona holding on by the narrowest of margins.

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